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Myopia Management for Eye Professionals

EVALUATING PRE-MYOPIA AND MYOPIA

Refractive Error

Graphic symbol representing myopia measurement by refractive error.
  • Primary method for diagnosing myopia and a routine measurement in every comprehensive eye examination1
  • Accuracy and repeatability improve with use of cycloplegia and objective measurements (autorefraction)2
  • Strongly correlated with axial length,3 but substantially less repeatable than optical biometry even with cycloplegia4,5
  • Misleading interpretation can occur with orthokeratology

Axial Length (Optical Biometry)

Graphic symbol of ruler representing myopia diagnosis by axial length measurement.
  • Primary metric for monitoring eye elongation
  • Highly repeatable measurement
  • Relates directly to the pathological processes in myopia
  • Doesn’t require cycloplegia
  • Less susceptible to changes in the anterior optics of the eye which may occur over the course of treatment such as orthokeratology

EVALUATING PRE-MYOPIA AND MYOPIA image

MONITORING PRE-MYOPIA AND MYOPIA

KEY POINTS FOR MONITORING image

Graphic symbol of eye accompanying key points of monitoring myopia and managing myopia.

Key Points for Monitoring

  • Young myopes will progress, so set this as the expectation6
  • Average treatment efficacy can be referenced from randomized clinical trials
  • Monitor Myopia management therapy use, acceptance, and maintenance every six months
  • Evaluate progression using at least one (1) year of data to avoid seasonal changes7 and reduce measurement noise (even with optical biometry)
  • Treatment efficacy cannot be determined for an individual patient because there is no way to know how that individual would have progressed if left untreated
  • Refer to population-based normative data to assess progression (see Table 5)

Myopia management therapy use, acceptance, and maintenance should be frequently monitored following treatment initiation or modification and at least every six (6) months once treatment is established. Frequent monitoring helps reduce barriers to use, identify non-compliant or risky behaviors, and address any problems as early as possible, supporting safe and consistent use of the myopia management therapy.Axial length and cycloplegic refractive error may be measured at frequent intervals but should be evaluated over at least one year before considering therapeutic changes or supplemental therapy because progression can vary seasonally.7Knowing efficacy is similar across treatments, it is most critical that the treatment regimen fits the patient’s lifestyle, expectations, motivation, and their abilities.
Key Points for Monitoring

KEY POINTS FOR MONITORING image

Graphic symbol of eye accompanying key points of monitoring myopia and managing myopia.

Key Points for Monitoring

  • Young myopes will progress, so set this as the expectation6
  • Average treatment efficacy can be referenced from randomized clinical trials
  • Monitor Myopia management therapy use, acceptance, and maintenance every six months
  • Evaluate progression using at least one (1) year of data to avoid seasonal changes7 and reduce measurement noise (even with optical biometry)
  • Treatment efficacy cannot be determined for an individual patient because there is no way to know how that individual would have progressed if left untreated
  • Refer to population-based normative data to assess progression (see Table 5)

Myopia management therapy use, acceptance, and maintenance should be frequently monitored following treatment initiation or modification and at least every six (6) months once treatment is established. Frequent monitoring helps reduce barriers to use, identify non-compliant or risky behaviors, and address any problems as early as possible, supporting safe and consistent use of the myopia management therapy.Axial length and cycloplegic refractive error may be measured at frequent intervals but should be evaluated over at least one year before considering therapeutic changes or supplemental therapy because progression can vary seasonally.7Knowing efficacy is similar across treatments, it is most critical that the treatment regimen fits the patient’s lifestyle, expectations, motivation, and their abilities.

Expected Progression without Myopia Management

Eye growth should be expected in all young patients, with even stable emmetropic eyes growing around 0.1 mm per year from age 6 to 14.9 Younger myopes will progress faster on average, with average rate of progression in 7-year-old children nearly double that of 11-year-old children.10 Individual progression near the mean values by age in Table 5 should not be considered normal or healthy, since any myopia progression will exponentially increase associated disease risk. Individual progression rates vary considerably across the population.11

EXPECTED PROGRESSION WITHOUT MYOPIA CONTROL image

Symbol of arrow pointing upwards over calendar, representing myopia progression over time as children advance in age.
Expected Progression without Myopia Management

Expected Progression without Myopia Management

Eye growth should be expected in all young patients, with even stable emmetropic eyes growing around 0.1 mm per year from age 6 to 14.9 Younger myopes will progress faster on average, with average rate of progression in 7-year-old children nearly double that of 11-year-old children.10 Individual progression near the mean values by age in Table 5 should not be considered normal or healthy, since any myopia progression will exponentially increase associated disease risk. Individual progression rates vary considerably across the population.11

EXPECTED PROGRESSION WITHOUT MYOPIA CONTROL image

Symbol of arrow pointing upwards over calendar, representing myopia progression over time as children advance in age.

Caution with Myopia Calculators

Myopia management calculators offer reasonable estimates of normal progression without myopia management therapy. The calculated myopia management effect, however, extrapolates a few years treatment effect for up to 11 years, omitting that treatment effect decreases over time and misleading users with overly optimistic treatment expectations.10

Review progression and compare to personalized goals

Sample Myopia Monitoring Schedule

Interim (6 months)
  • Focused history including at a minimum:
    • Care and maintenance of therapy
    • Frequency and usage of therapy
    • Patient acceptance and satisfaction with therapy
  • Visual acuity
  • Binocular vision and accommodation (can be impacted by myopia management therapy)
  • Measure axial length (if possible) and refractive error
  • Assess therapy-related ocular health
  • Additional testing as indicated by myopia management therapy

Annual (12 months)
  • Comprehensive eye exam (w/cycloplegic refractive error if possible)
  • Review myopia management therapy (as described above)
  • Measure axial length (if possible)
  • Review progression and compare to personalized goals

Review progression and compare to personalized goals

Caution with Myopia Calculators

Caution with Myopia Calculators

Myopia management calculators offer reasonable estimates of normal progression without myopia management therapy. The calculated myopia management effect, however, extrapolates a few years treatment effect for up to 11 years, omitting that treatment effect decreases over time and misleading users with overly optimistic treatment expectations.10

Review progression and compare to personalized goals

Sample Myopia Monitoring Schedule

Interim (6 months)
  • Focused history including at a minimum:
    • Care and maintenance of therapy
    • Frequency and usage of therapy
    • Patient acceptance and satisfaction with therapy
  • Visual acuity
  • Binocular vision and accommodation (can be impacted by myopia management therapy)
  • Measure axial length (if possible) and refractive error
  • Assess therapy-related ocular health
  • Additional testing as indicated by myopia management therapy

Annual (12 months)
  • Comprehensive eye exam (w/cycloplegic refractive error if possible)
  • Review myopia management therapy (as described above)
  • Measure axial length (if possible)
  • Review progression and compare to personalized goals

Review progression and compare to personalized goals

DETERMINING MYOPIA MANAGEMENT EFFICACY

Communicating Myopia Management Efficacy

While “percentage treatment” effect is easy to understand, it leads to inconsistent representation across the progression range and fails to capture that myopia management efficacy slows over time. Myopia management treatment effect tends to be more of an absolute effect than a proportional effect.10

Table 5

Table showing mean progression of myopia in Asian and non-Asian children by axial length from ages 7 to 11.
Table 5: Mean progression for myopic Asians and non-Asians by axial length and refractive error across age6

PERSONALIZING MYOPIA MANAGEMENT THERAPY

Treatments for myopia management have been investigated in clinical studies for their effectiveness and safety. Choosing the right one will depend on the individual patient's lifestyle, age, maturity, and refractive error. This diagram can be helpful in guiding your conversation with patients and their parents.

Clinical Considerations

Clinical Considerations

Refractive error and astigmatism
Myopia management treatment history
Ocular health
Vision quality
Efficacy

Lifestyle Considerations

Sports/physical activity
Swimming or water activity
Patient responsibility/hygiene
Patient or parent preference
Desire for parental oversight.

REFERENCES

1. American Optometric Association, Comprehensive Pediatric Eye and Vision Examination. https://www.aoa.org/AOA/Documents/Practice%20Management/Clinical%20Guidelines/EBO%20Guidelines/Comprehensive%20Pediatric%20Eye%20and%20Vision%20Exam.pdf, accessed September 3, 2020.
2. Morgan, Ian G., et al. Cycloplegic refraction is the gold standard for epidemiological studies. Acta Ophthalmologica 93.6 (2015): 581-585.
3. Hou, Wei, et al. Axial elongation in myopic children and its association with myopia progression in the Correction of Myopia Evaluation Trial (COMET). Eye & contact lens 44.4 (2018): 248.
4. Buckhurst, Phillip Jonathan, et al. “A new optical low coherence reflectometry device for ocular biometry in cataract patients.” British Journal of Ophthalmology 93.7 (2009): 949-953.
5. Bullimore, Mark A.et al. “The repeatability of automated and clinician refraction.” Optometry and Vision Science: Official Publication of the American Academy of Optometry 75.8 (1998): 617-622.
6. Donovan L et al. Myopia progression rates in urban children wearing single-vision spectacles. Optom Vis Sci 2012;89:27-32.
7. Gwiazda J, Deng L, Manny R, Norton TT; COMET Study Group. Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci. 2014 Feb 4;55(2):752-8.
9. Mutti DO, Hayes JR, Mitchell GL et al. Refractive Error, Axial Length, and Relative Peripheral Refractive Error before and after the Onset of Myopia. Invest Ophthalmol Vis Sci 2007;48:2510-9.
10. Brennan NA, Cheng X. Commonly Held Beliefs About Myopia That Lack a Robust Evidence Base. Eye Contact Lens 2019;45:215-25.
11. Chua SY et al. Age of Onset of Myopia Predicts Risk of High Myopia in Later Childhood in Myopic Singapore Children. Opthal Physiol Opt 2016;36:388-94.

PP2021ABLM4027
REFERENCES

REFERENCES

1. American Optometric Association, Comprehensive Pediatric Eye and Vision Examination. https://www.aoa.org/AOA/Documents/Practice%20Management/Clinical%20Guidelines/EBO%20Guidelines/Comprehensive%20Pediatric%20Eye%20and%20Vision%20Exam.pdf, accessed September 3, 2020.
2. Morgan, Ian G., et al. Cycloplegic refraction is the gold standard for epidemiological studies. Acta Ophthalmologica 93.6 (2015): 581-585.
3. Hou, Wei, et al. Axial elongation in myopic children and its association with myopia progression in the Correction of Myopia Evaluation Trial (COMET). Eye & contact lens 44.4 (2018): 248.
4. Buckhurst, Phillip Jonathan, et al. “A new optical low coherence reflectometry device for ocular biometry in cataract patients.” British Journal of Ophthalmology 93.7 (2009): 949-953.
5. Bullimore, Mark A.et al. “The repeatability of automated and clinician refraction.” Optometry and Vision Science: Official Publication of the American Academy of Optometry 75.8 (1998): 617-622.
6. Donovan L et al. Myopia progression rates in urban children wearing single-vision spectacles. Optom Vis Sci 2012;89:27-32.
7. Gwiazda J, Deng L, Manny R, Norton TT; COMET Study Group. Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci. 2014 Feb 4;55(2):752-8.
9. Mutti DO, Hayes JR, Mitchell GL et al. Refractive Error, Axial Length, and Relative Peripheral Refractive Error before and after the Onset of Myopia. Invest Ophthalmol Vis Sci 2007;48:2510-9.
10. Brennan NA, Cheng X. Commonly Held Beliefs About Myopia That Lack a Robust Evidence Base. Eye Contact Lens 2019;45:215-25.
11. Chua SY et al. Age of Onset of Myopia Predicts Risk of High Myopia in Later Childhood in Myopic Singapore Children. Opthal Physiol Opt 2016;36:388-94.

PP2021ABLM4027